| Date: | 4–10 June |
| Edition: | 11th |
| Category: | ITF Women's Circuit |
| Location: | Brescia, Italy |
| Prize Money: | $60,000 |
| Champs: |  Kaia Kanepi |
| Champd: |  Cristina Dinu /  Ganna Poznikhirenko |
The 2018 Internazionali Femminili di Brescia was a professional tennis tournament played on outdoor clay courts. It was the eleventh edition of the tournament and was part of the 2018 ITF Women's Circuit. It took place in Brescia, Italy, on 4–10 June 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Estonia | Kaia Kanepi | 52 | 1 | |
| Romania | Alexandra Dulgheru | 159 | 2 | |
 Italy | Deborah Chiesa | 161 | 3 | |
 Liechtenstein | Kathinka von Deichmann | 171 | 4 | |
 Turkey | Çağla Büyükakçay | 181 | 5 | |
| Italy | Martina Trevisan | 185 | 6 | |
 United States | Francesca Di Lorenzo | 188 | 7 | |
| United States | Kayla Day | 189 | 8 |
The following players received a wildcard into the singles main draw:
The following players received entry using protected rankings:
The following players received entry from the qualifying draw:
See main article: 2018 Internazionali Femminili di Brescia – Singles.
Kaia Kanepi def. Martina Trevisan, 6–4, 6–3 Cristina Dinu / Ganna Poznikhirenko def. 
Alexandra Panova / Anastasia Pribylova, 6–3, 7–6(8–6)
