| Date: | 5–11 November |
| Edition: | 6th |
| Surface: | Hard |
| Location: | Mouilleron-le-Captif, France |
| Champs: |  Elias Ymer |
| Champd: |  Sander Gillé / Joran Vliegen |
The 2018 Internationaux de Tennis de Vendée was a professional tennis tournament played on hard courts. It was the sixth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Mouilleron-le-Captif, France between 5 and 11 November 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 France | Benoît Paire | 56 | 1 | |
 Serbia | Laslo Đere | 92 | 2 | |
| France | Ugo Humbert | 99 | 3 | |
 Canada | ||||
 Lithuania | Ričardas Berankis | 117 | 5 | |
| Yannick Maden | 128 | 6 | ||
| Sweden | Elias Ymer | 132 | 7 | |
 Italy | Stefano Travaglia | 133 | 8 |
The following players received wildcards into the singles main draw:
Mathias Bourgue Enzo Couacaud Tom Jomby Matteo MartineauThe following players received entry into the singles main draw as special exempts:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2018 Internationaux de Tennis de Vendée – Singles.
Elias Ymer def. Yannick Maden 6–3, 7–6(7–5).See main article: 2018 Internationaux de Tennis de Vendée – Doubles.
Sander Gillé / Joran Vliegen def. Romain Arneodo / Quentin Halys 6–3, 4–6, [10–2].