See main article: article and 2018 Internationaux de Strasbourg.
Samantha Stosur was the defending champion but lost in the quarterfinals to Dominika Cibulková.
Anastasia Pavlyuchenkova won the title, defeating Cibulková in the final, 6–7(5–7), 7–6(7–3), 7–6(8–6). Pavlyuchenkova won the title after saving two match points Cibulková had in the final against her.