| Date: | 3–9 September |
| Edition: | 2nd |
| Surface: | Hard |
| Location: | Zhangjiagang, China |
| Champs: |  Yasutaka Uchiyama |
| Champd: |  Gong Maoxin / Zhang Ze |
The 2018 International Challenger Zhangjiagang was a professional tennis tournament played on hard courts. It was the second edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Zhangjiagang, China between 3 and 9 September 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Jason Jung | 115 | 1 | ||
| Japan | Tatsuma Ito | 163 | 2 | |
| China | Zhang Ze | 168 | 3 | |
| Japan | Go Soeda | 176 | 4 | |
 Canada | Filip Peliwo | 185 | 5 | |
 Serbia | Miomir Kecmanović | 196 | 6 | |
| Japan | Hiroki Moriya | 197 | 7 | |
 Kazakhstan | Alexander Bublik | 203 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2018 International Challenger Zhangjiagang – Singles.
Yasutaka Uchiyama def. Jason Jung 6–2, 6–2.See main article: 2018 International Challenger Zhangjiagang – Doubles.
Gong Maoxin / Zhang Ze def. 
Bradley Mousley / Akira Santillan walkover.