| Date: | 16–22 April |
| Edition: | 18th |
| Category: | ITF Women's Circuit |
| Location: | Dothan, United States |
| Prize Money: | $80,000 |
| Champs: |  Taylor Townsend |
| Champd: | Alexa Guarachi /  Erin Routliffe |
The 2018 Hardee's Pro Classic was a professional tennis tournament played on outdoor clay courts. It was the eighteenth edition of the tournament and was part of the 2018 ITF Women's Circuit. It took place in Dothan, United States, on 16–22 April 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| United States | Jennifer Brady | 85 | 1 | |
| United States | Sofia Kenin | 86 | 2 | |
| United States | Kristie Ahn | 109 | 3 | |
| United States | Taylor Townsend | 113 | 4 | |
 Colombia | Mariana Duque Mariño | 123 | 5 | |
 Russian Federation | Sofya Zhuk | 128 | 6 | |
| United States | Jamie Loeb | 160 | 7 | |
 Australia | Lizette Cabrera | 162 | 8 |
The following players received a wildcard into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2018 Hardee's Pro Classic – Singles.
Taylor Townsend def. Mariana Duque Mariño, 6–2, 2–6, 6–1 Erin Routliffe def. Sofia Kenin / Jamie Loeb, 6–4, 2–6, [11–9]
