| Date: | 11–17 June |
| Edition: | 2nd |
| Category: | ITF Women's Circuit |
| Location: | Manchester, United Kingdom |
| Prize Money: | $100,000 |
| Champs: |  Ons Jabeur |
| Champd: |  Luksika Kumkhum /  Prarthana Thombare |
| Before Name: | Aegon Manchester Trophy |
| Main Name: | Manchester Trophy Challenger Manchester Trophy |
| After Name: | Manchester Trophy |
The 2018 Fuzion 100 Manchester Trophy was a professional tennis tournament played on outdoor grass courts. It was the second edition of the tournament and was part of the 2018 ITF Women's Circuit. It took place in Manchester, United Kingdom, on 11–17 June 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 United States | Jennifer Brady | 86 | 1 | |
| Thailand | Luksika Kumkhum | 100 | 2 | |
| Viktorija Golubic | 110 | 3 | ||
| United States | Nicole Gibbs | 113 | 4 | |
 Spain | Sara Sorribes Tormo | 114 | 5 | |
 Russian Federation | Evgeniya Rodina | 116 | 6 | |
 United Kingdom | Naomi Broady | 120 | 7 | |
 Italy | Jasmine Paolini | 130 | 8 |
The following players received a wildcard into the singles main draw:
The following players received entry from the qualifying draw:
Eden Richardson Maria SanchezSee main article: article and 2018 Fuzion 100 Manchester Trophy – Singles.
Ons Jabeur def. Sara Sorribes Tormo, 6–2, 6–1See main article: article and 2018 Fuzion 100 Manchester Trophy – Doubles.
Luksika Kumkhum / Prarthana Thombare def. Naomi Broady / Asia Muhammad, 7–6(7–5), 6–3
