| Date: | 18–24 June |
| Edition: | 19th (men) 8th (women) |
| Surface: | Hard |
| Location: | Fergana, Uzbekistan |
| Champms: |  Nikola Milojević |
| Champws: |  Nigina Abduraimova |
| Champmd: |  Ivan Gakhov / Alexander Pavlioutchenkov |
| Champwd: | Anastasia Frolova / Ekaterina Yashina |
The 2018 Fergana Challenger is a professional tennis tournament played on hard courts. It is the 19th edition of the tournament for men which is part of the 2018 ATP Challenger Tour, and the eighth edition of the event for women on the 2018 ITF Women's Circuit. It takes place in Fergana, Uzbekistan between 18–24 June 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Serbia | Nikola Milojević | 187 | 1 | |
 Spain | Enrique López Pérez | 208 | 2 | |
| Gonçalo Oliveira | 227 | 3 | ||
 Korea, Republic of | Lee Duck-hee | 229 | 4 | |
| Russian Federation | Ivan Nedelko | 238 | 5 | |
 Belarus | Egor Gerasimov | 245 | 6 | |
 Dominican Republic | Roberto Cid Subervi | 248 | 7 | |
 Japan | Yosuke Watanuki | 252 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Konstantin Kravchuk
Saketh Myneni Shuichi Sekiguchi| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Uzbekistan | Sabina Sharipova | 144 | 1 | |
| Russian Federation | Olga Doroshina | 270 | 2 | |
| Uzbekistan | Nigina Abduraimova | 329 | 3 | |
 Ukraine | Valeriya Strakhova | 338 | 4 | |
| Nastja Kolar | 383 | 5 | ||
| Russian Federation | Varvara Flink | 395 | 6 | |
| India | Rutuja Bhosale | 403 | 7 | |
| Russian Federation | Anna Morgina | 408 | 8 |
The following players received wildcards into the singles main draw:
Nigora Azimjanova Nasiba Espolova Arina Folts Elina SharipovaThe following players received entry from the qualifying draw:
Isabella Bozicevic Sai Samhitha Chamarthi Ilona Kremen Natasha Palha Kamilla Rakhimova
Vitalia Stamat Sadafmoh Tolibova Guzal YusupovaSee main article: 2018 Fergana Challenger – Men's singles.
Nikola Milojević def. Enrique López Pérez 6–3, 6–4. Nigina Abduraimova def. Anastasia Frolova, 6–3, 2–0 ret.See main article: 2018 Fergana Challenger – Men's doubles.
Ivan Gakhov / Alexander Pavlioutchenkov def. Saketh Myneni / Vijay Sundar Prashanth 6–4, 6–4. Anastasia Frolova / Ekaterina Yashina def. Sofya Lansere / Kamilla Rakhimova, 6–1, 7–6(7–4)