| Date: | 14–20 May |
| Edition: | 10th |
| Category: | ITF Women's Circuit |
| Location: | Trnava, Slovakia |
| Surface: | Clay |
| Prize Money: | $100,000 |
| Champs: |  Viktória Kužmová |
| Champd: |  Jessica Moore /  Galina Voskoboeva |
The 2018 Empire Slovak Open was a professional tennis tournament played on outdoor clay courts. It was the tenth edition of the tournament and was part of the 2018 ITF Women's Circuit. It took place in Trnava, Slovakia, on 14–20 May 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Sweden | Johanna Larsson | 79 | 1 | |
| Slovakia | Anna Karolína Schmiedlová | 84 | 2 | |
| Verónica Cepede Royg | 88 | 3 | ||
 Japan | Kurumi Nara | 91 | 4 | |
 United States | Madison Brengle | 99 | 5 | |
| Stefanie Vögele | 100 | 6 | ||
 Belgium | Yanina Wickmayer | 101 | 7 | |
 Russian Federation | Ekaterina Alexandrova | 102 | 8 |
The following players received a wildcard into the singles main draw:
Tereza Mihalíková Lenka Stará Rebecca Šramková Vera ZvonarevaThe following players received entry from the qualifying draw:
Maja Chwalińska Vivien Juhászová
Tereza Martincová Anastasia PotapovaThe following player received entry as a lucky loser:
See main article: 2018 Empire Slovak Open – Singles.
Viktória Kužmová def. Verónica Cepede Royg, 6–4, 1–6, 6–1 Jessica Moore / Galina Voskoboeva def. Xenia Knoll / 
Anna Smith, 0–6, 6–3, [10–7]