| Champ: |  Roberto Carballés Baena |
| Runner: | Albert Ramos Viñolas |
| Score: | 6–3, 4–6, 6–4 |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| Type: | singles doubles |
| Before Name: | Ecuador Open Quito – Singles |
| After Name: | Ecuador Open Quito – Singles |
| After Year: | no |
See main article: 2018 Ecuador Open Quito. Víctor Estrella Burgos was the three-time defending champion and the tournament's only champion to date, but lost in the second round to Gerald Melzer.
Roberto Carballés Baena won his first ATP title, defeating Albert Ramos Viñolas in the final, 6–3, 4–6, 6–4.
The top four seeds receive a bye into the second round.
The top two seeds receive a bye into the qualifying competition.
