See main article: article and 2018 Ecuador Open Quito.
James Cerretani and Philipp Oswald were the defending champions, but Cerretani chose to compete in Sofia instead. Oswald played alongside Treat Huey, but lost in the first round to Alessandro Motti and Stefano Travaglia.
Nicolás Jarry and Hans Podlipnik-Castillo won the title, defeating Austin Krajicek and Jackson Withrow in the final, 7–6(8–6), 6–3.