The 2018 Ecuador Open Quito was an ATP men's tennis tournament played on outdoor clay courts. It was the 4th edition of the Ecuador Open Quito as part of the ATP World Tour 250 series of the 2018 ATP World Tour. It took place in Quito, Ecuador from 5 February through 11 February 2018. Unseeded Roberto Carballés Baena, who entered the main draw as a qualifier, won the singles title.
| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q | width=85 | Q2 | width=85 | Q1 |
| Singles | 250 | 150 | 90 | 45 | 20 | 0 | 12 | 6 | 0 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Doubles | 0 |
| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q2 | width=85 | Q1 |
| Singles | $85,945 | $45,265 | $24,520 | $13,970 | $8,230 | $4,875 | $2,195 | $1,100 | ||
| Doubles | $26,110 | $13,730 | $7,440 | $4,260 | $2,490 | |||||
| Doubles prize money per team | ||||||||||
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Pablo Carreño Busta | 10 | 1 | |
| Spain | Albert Ramos Viñolas | 21 | 2 | |
 France | Gaël Monfils | 44 | 3 | |
 Italy | Paolo Lorenzi | 46 | 4 | |
 Argentina | Horacio Zeballos | 66 | 5 | |
 Dominican Republic | Víctor Estrella Burgos | 86 | 6 | |
| Ivo Karlović | 90 | 7 | ||
| Nicolás Jarry | 95 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry using a protected ranking:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Alexandr Dolgopolov → replaced by 
Casper Ruud Nicolás Kicker → replaced by 
Peter Polansky Tommy Robredo → replaced by Alessandro Giannessi
Tennys Sandgren → replaced by Stefano Travaglia| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 Brazil | Marcelo Demoliner |  India | Purav Raja | 98 | 1 | |
| Treat Huey |  Austria | Philipp Oswald | 111 | 2 | ||
 Mexico | Santiago González | Mexico | Miguel Ángel Reyes Varela | 127 | 3 | |
| Spain | Pablo Carreño Busta | Argentina | Guillermo Durán | 148 | 4 |
The following pairs received wildcards into the doubles main draw:
The following pairs received entry as alternates:
Carlos Berlocq (right shoulder injury) Rogério Dutra Silva (enteritis) André Sá (right calf strain)See main article: 2018 Ecuador Open Quito – Singles.
Roberto Carballés Baena defeated Albert Ramos Viñolas, 6–3, 4–6, 6–4See main article: 2018 Ecuador Open Quito – Doubles.
Austin Krajicek / Jackson Withrow, 7–6(8–6), 6–3
