| Champ: | Caroline Wozniacki |
| Runner: |  Aryna Sabalenka |
| Score: | 7–5, 7–6(7–5) |
| Draw: | 48 (6 / 4) |
| Seeds: | 16 |
| Before Name: | Aegon International Eastbourne – Women's singles |
See main article: article and 2018 Eastbourne International.
Karolína Plíšková was the defending champion, but lost in the quarterfinals to Aryna Sabalenka.
Caroline Wozniacki won the title, defeating Sabalenka in the final 7–5, 7–6(7–5). Wozniacki won the title after saving a match point Angelique Kerber had against her in the semifinals.
All seeds received a bye into the second round.
The top three seeds received a bye into the qualifying competition.
