| Champ: |  Salvatore Caruso |
| Runner: | Cristian Garín |
| Score: | 7–5, 6–4 |
| Type: | singles doubles |
See main article: article and 2018 Città di Como Challenger.
Pedro Sousa was the defending champion but lost in the first round to Cristian Garín.
Salvatore Caruso won the title after defeating Garín 7–5, 6–4 in the final.