The 2018 Chennai Open Challenger was a professional tennis tournament played on hard courts. It was the first edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Chennai, India between 12 and 17 February 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Australia | Jordan Thompson | 103 | 1 | |
 India | Yuki Bhambri | 112 | 2 | |
 Korea, Republic of | Lee Duck-hee | 207 | 3 | |
 Egypt | Mohamed Safwat | 218 | 4 | |
| India | Sumit Nagal | 220 | 5 | |
 Japan | Yasutaka Uchiyama | 226 | 6 | |
 Spain | Enrique López Pérez | 229 | 7 | |
| India | Prajnesh Gunneswaran | 242 | 8 |
The following players received wildcards into the singles main draw:
Vijay Sundar Prashanth Nitin Kumar Sinha Dhakshineswar Suresh Manish SureshkumarThe following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
Arjun Kadhe Sidharth Rawat Abhinav Sanjeev Shanmugam
Wishaya TrongcharoenchaikulSee main article: 2018 Chennai Open Challenger – Singles.
Jordan Thompson def. Yuki Bhambri 7–5, 3–6, 7–5.See main article: 2018 Chennai Open Challenger – Doubles.
Sriram Balaji / Vishnu Vardhan def. 
Cem İlkel / 
Danilo Petrović 7–6(7–5), 5–7, [10–5].