| Date: | 12–18 November |
| Edition: | 8th |
| Surface: | Clay |
| Location: | Buenos Aires, Argentina |
| Champs: |  Pablo Andújar |
| Champd: |  Guido Andreozzi / Guillermo Durán |
| Before Name: | Copa Fila |
The 2018 Challenger de Buenos Aires was a professional tennis tournament played on clay courts. It was the eighth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Buenos Aires, Argentina between 12 and 18 November 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Argentina | Guido Andreozzi | 82 | 1 | |
| Spain | Pablo Andújar | 101 | 2 | |
 Brazil | Thiago Monteiro | 112 | 3 | |
| Pedro Sousa | 114 | 4 | ||
 Bolivia, Plurination;al State of | Hugo Dellien | 117 | 5 | |
| Argentina | Carlos Berlocq | 127 | 6 | |
 Italy | Gianluigi Quinzi | 149 | 7 | |
| Argentina | Facundo Bagnis | 150 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Federico Coria Orlando Luz Gonzalo VillanuevaSee main article: 2018 Challenger de Buenos Aires – Singles.
Pablo Andújar def. Pedro Cachin 6–3, 6–1.See main article: 2018 Challenger de Buenos Aires – Doubles.
Guido Andreozzi / Guillermo Durán def. Marcelo Demoliner / Andrés Molteni 6–4, 4–6, [10–3].