| Date: | 24–30 September |
| Edition: | 2nd |
| Category: | ITF Women's Circuit |
| Location: | Templeton, United States |
| Prize Money: | $60,000 |
| Champs: |  Asia Muhammad |
| Champd: | Asia Muhammad / Maria Sanchez |
The 2018 Central Coast Pro Tennis Open was a professional tennis tournament played on outdoor hard courts. It was the second edition of the tournament and was part of the 2018 ITF Women's Circuit. It took place in Templeton, United States, on 24–30 September 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| United States | Taylor Townsend | 64 | 1 | |
| United States | Madison Brengle | 100 | 2 | |
 Brazil | Beatriz Haddad Maia | 126 | 3 | |
| United States | Jessica Pegula | 141 | 4 | |
| United States | Kristie Ahn | 142 | 5 | |
 Russian Federation | Sofya Zhuk | 148 | 6 | |
 Czech Republic | Marie Bouzková | 153 | 7 | |
| United States | Jamie Loeb | 163 | 8 |
The following players received a wildcard into the singles main draw:
Danielle Lao Ann Li Taylor Townsend Sophia WhittleThe following players received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
See main article: 2018 Central Coast Pro Tennis Open – Singles.
Asia Muhammad def. Sesil Karatantcheva, 2–6, 6–4, 6–3See main article: 2018 Central Coast Pro Tennis Open – Doubles.
Asia Muhammad / Maria Sanchez def. Quinn Gleason / Luisa Stefani, 6–7(4–7), 6–2, [10–8]
