| Date: | 15–21 October |
| Edition: | 1st |
| Surface: | Hard (indoor) |
| Location: | Calgary, Canada |
| Champs: | Ivo Karlović |
| Champd: |  Robert Galloway / Nathan Pasha |
| After Year: | 2020 |
The 2018 Calgary National Bank Challenger was a professional tennis tournament played on indoor hard courts. It was the first edition of the tournament and part of the 2018 ATP Challenger Tour. It took place in Calgary, Canada.
| Country | Player | Rank | Seed | |
|---|---|---|---|---|
 Australia | Jordan Thompson | 105 | 1 | |
| Ivo Karlović | 117 | 2 | ||
| Jason Jung | 123 | 3 | ||
 Spain | Adrián Menéndez Maceiras | 132 | 4 | |
 Norway | Casper Ruud | 137 | 5 | |
| Australia | ||||
 United Kingdom | Jay Clarke | 177 | 7 | |
 Ecuador | Roberto Quiroz | 190 | 8 |
The following players received wildcards into the singles main draw:
Steven Diez Alexis Galarneau Pavel Krainik Harrison ScottThe following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Tom Fawcett
Vincent Millot Pablo Vivero GonzálezThe following player received entry as a lucky loser:
Laurent RochetteSee main article: 2018 Calgary National Bank Challenger – Singles.
Jordan Thompson 7–6(7–3), 6–3.See main article: 2018 Calgary National Bank Challenger – Doubles.
Robert Galloway / Nathan Pasha def. Matt Reid / John-Patrick Smith 6–4, 4–6, [10–6].