| Date: | 9–15 April |
| Edition: | 1st |
| Surface: | Clay |
| Location: | Mexico City, Mexico |
| Champs: |  Juan Ignacio Londero |
| Champd: | Yannick Hanfmann / Kevin Krawietz |
| After Year: | no |
The 2018 CDMX Open was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Mexico City, Mexico between 9 and 15 April 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Yannick Hanfmann | 121 | 1 | ||
 Brazil | Thiago Monteiro | 125 | 2 | |
| Argentina | Carlos Berlocq | 131 | 3 | |
 Spain | Adrián Menéndez Maceiras | 140 | 4 | |
| Mats Moraing | 156 | 5 | ||
 Dominican Republic | Víctor Estrella Burgos | 160 | 6 | |
| Marcelo Arévalo | 175 | 7 | ||
 Serbia | Peđa Krstin | 206 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following players received entry from the qualifying draw:
See main article: 2018 CDMX Open – Singles.
Juan Ignacio Londero def. 
Roberto Quiroz 6–1, 6–3.See main article: 2018 CDMX Open – Doubles.
Luke Bambridge / Jonny O'Mara 6–2, 7–6(7–3).
