The 2018 CAF Champions League knockout stage was played from 14 September to 9 November 2018.[1] A total of eight teams competed in the knockout stage to decide the champions of the 2018 CAF Champions League.[2]
The winners and runners-up of each of the four groups in the group stage advanced to the quarter-finals.
| Group | width=200 | Winners | width=200 | Runners-up |
|---|---|---|---|---|
| A |  Al Ahly |  Espérance de Tunis | ||
| B |  TP Mazembe | ES Sétif | ||
| C |  Wydad AC | Horoya | ||
| D | Étoile du Sahel | 1º de Agosto |
In the knockout stage, the eight teams played a single-elimination tournament. Each tie was played on a home-and-away two-legged basis. If the aggregate score was tied after the second leg, the away goals rule would be applied, and if still tied, extra time would not be played, and the penalty shoot-out would be used to determine the winner (Regulations III. 26 & 27).[2]
The schedule of each round was as follows (matches scheduled in midweek in italics).[1] Effective from the Champions League group stage, weekend matches were played on Fridays and Saturdays while midweek matches were played on Tuesdays, with some exceptions. Kick-off times were also fixed at 13:00 (Saturdays and Tuesdays only), 16:00 and 19:00 GMT.[3]
| Round | First leg | Second leg | |
|---|---|---|---|
| Quarter-finals | 14–15 September 2018 | 21–22 September 2018 | |
| Semi-finals | 2 October 2018 | 23 October 2018 | |
| Final | 2 November 2018 | 9 November 2018 |
The bracket of the knockout stage was determined as follows:[2]
| Round | Matchups | |
|---|---|---|
| Quarter-finals | (Group winners host second leg, matchups decided by draw, teams from same group cannot play each other)
| |
| Semi-finals | (Matchups and order of legs decided by draw, between winners QF1, QF2, QF3, QF4)
| |
| Final | (Winners SF1 host first leg, Winners SF2 host second leg)
|
In the quarter-finals, the winners of one group played the runners-up of another group (teams from same group could not play each other), with the group winners hosting the second leg, and the matchups decided by draw.[4]
|}
1–1 on aggregate. 1º de Agosto won on away goals.----Espérance de Tunis won 3–1 on aggregate.----ES Sétif won 1–0 on aggregate.----Al-Ahly won 4–0 on aggregate.
In the semi-finals, the four quarter-final winners played in two ties, with the matchups and order of legs decided by draw.[4]
|}
Al-Ahly won 3–2 on aggregate.----Espérance de Tunis won 4–3 on aggregate.
See main article: article and 2018 CAF Champions League Final. In the final, the two semi-final winners played each other, with the order of legs determined by the semi-final draw.[4] Espérance de Tunis won 4–3 on aggregate.