| Champ: |  Nick Kyrgios |
| Runner: |  Ryan Harrison |
| Score: | 6–4, 6–2 |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| After Name: | Brisbane International – Men's singles |
| Before Name: | Brisbane International – Men's singles |
See main article: 2018 Brisbane International.
Grigor Dimitrov was the defending champion, but lost in the semifinals to Nick Kyrgios.
Kyrgios went on to win the title, defeating Ryan Harrison in the final, 6–4, 6–2.
The top four seeds receive a bye into the second round.