| Champ: | Diede de Groot |
| Runner: |  Yui Kamiji |
| Score: | 7–6(8–6), 6–4 |
| Before Name: | Australian Open – Wheelchair women's singles |
See main article: 2018 Australian Open.
Diede de Groot defeated the defending champion Yui Kamiji in the final, 7–6(8–6), 6–4 to win the women's singles wheelchair tennis title at the 2018 Australian Open.