See main article: 2018 Australian Open.
Marjolein Buis and Yui Kamiji defeated the defending champion Aniek van Koot and her partner Diede de Groot in the final, 6–0, 6–4 to win the women's doubles wheelchair tennis title at the 2018 Australian Open.
Jiske Griffioen and van Koot were the reigning champions, but Griffioen did not participate.