| Champ: |  Dylan Alcott |
| Runner: |  David Wagner |
| Score: | 7–6(7–1), 6–1 |
| Before Name: | Australian Open – Wheelchair quad singles |
See main article: 2018 Australian Open.
Three-time defending champion Dylan Alcott defeated David Wagner in the final, 7–6(7–1), 6–1 to win the quad singles wheelchair tennis title at the 2018 Australian Open.