| Champ: |  Shingo Kunieda |
| Runner: |  Stéphane Houdet |
| Score: | 4–6, 6–1, 7–6(7–3) |
| Before Name: | Australian Open – Wheelchair men's singles |
See main article: 2018 Australian Open.
Shingo Kunieda defeated Stéphane Houdet in the final, 4–6, 6–1, 7–6(7–3) to win the men's singles wheelchair tennis title at the 2018 Australian Open. It was his ninth Australian Open singles title and 21st major singles title overall, and his first major championship in over two years.
Gustavo Fernández was the defending champion, but was defeated Nicolas Peifer in the quarterfinals in a rematch of the previous year's final.