| Champ: |  Damir Džumhur |
| Runner: |  Adrian Mannarino |
| Score: | 6–1, 1–6, 6–1 |
| Edition: | 2nd |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| Type: | singles doubles |
See main article: 2018 Antalya Open.
Damir Džumhur defeated Adrian Mannarino in the final, 6–1, 1–6, 6–1, to win the singles title at the 2018 Antalya Open.
Yūichi Sugita was the defending champion, but lost in the second round to Pierre-Hugues Herbert.
The top four seeds receive a bye into the second round.