| Date: | 23–29 July |
| Edition: | 25th (ATP) 14th (ITF) |
| Category: | ATP Challenger Tour ITF Women's Circuit |
| Location: | Prague, Czech Republic |
| Venue: | I. Czech Lawn Tennis Club |
| Prize Money: | €42,500 (ATP) $80,000 (ITF) |
| Champms: |  Lukáš Rosol |
| Champws: | Richèl Hogenkamp |
| Champmd: |  Sander Gillé / Joran Vliegen |
| Champwd: |  Cornelia Lister /  Nina Stojanović |
The 2018 Advantage Cars Prague Open, also known as Advantage Cars Prague Open by Sport-Technik Bohemia for sponsorship reasons, was a professional tennis tournament played on outdoor clay courts. It was the 25th (ATP) and fourth (ITF) editions of the tournament and was part of the 2018 ATP Challenger Tour and also of the 2018 ITF Women's Circuit as 14th edition of the tournament. It took place in Prague, Czech Republic, on 23–29 July 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Yannick Maden | 132 | 1 | ||
 Brazil | Rogério Dutra Silva | 138 | 2 | |
| Mats Moraing | 149 | 3 | ||
 Spain | Enrique López Pérez | 154 | 4 | |
| Czech Republic | Adam Pavlásek | 158 | 5 | |
 Hungary | Attila Balázs | 160 | 6 | |
| Oscar Otte | 183 | 7 | ||
| Spain | Pedro Martínez | 190 | 8 |
The following players received wildcards into the singles main draw:
Marek Podlešák Patrik Rikl Jan Šátral
Dominik ŠprochThe following players received entry into the singles main draw as special exempts:
The following players received entry from the qualifying draw:
Filip Horanský Pavel Nejedlý| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Mona Barthel | 115 | 1 | ||
| Richèl Hogenkamp | 156 | 2 | ||
| Tamara Korpatsch | 158 | 3 | ||
| Czech Republic | Tereza Smitková | 165 | 4 | |
| Bibiane Schoofs | 174 | 5 | ||
 Italy | Jasmine Paolini | 180 | 6 | |
| Czech Republic | Barbora Krejčíková | 183 | 7 | |
| Elitsa Kostova | 186 | 8 |
The following players received a wildcard into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2018 Advantage Cars Prague Open – Men's singles.
Lukáš Rosol def. 
Aleksandr Nedovyesov 4–6, 6–3, 6–4.See main article: 2018 Advantage Cars Prague Open – Women's singles.
Martina Di Giuseppe, 6–4, 6–2See main article: 2018 Advantage Cars Prague Open – Men's doubles.
Sander Gillé / Joran Vliegen def. Fernando Romboli / David Vega Hernández 6–4, 6–2.See main article: 2018 Advantage Cars Prague Open – Women's doubles.
Cornelia Lister / Nina Stojanović def. Bibiane Schoofs / Kimberley Zimmermann, 6–2, 2–6, [10–8]
