The 2018 ATP Shenzhen Open was a professional men's tennis tournament played on hard courts. It was the 5th edition of the tournament, and part of the ATP World Tour 250 series of the 2018 ATP World Tour. It took place at the Shenzhen Longgang Tennis Centre in Shenzhen, China from September 24 to 30.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Belgium | David Goffin | 11 | 1 | |
| Stefanos Tsitsipas | 15 | 2 | ||
| Borna Ćorić | 18 | 3 | ||
 Bosnia and Herzegovina | Damir Džumhur | 28 | 4 | |
 Spain | Fernando Verdasco | 29 | 5 | |
 Canada | Denis Shapovalov | 34 | 6 | |
 Australia | Alex de Minaur | 38 | 7 | |
 Italy | Andreas Seppi | 47 | 8 |
The following players received entry from the qualifying draw:
Denis Istomin →replaced by 
Mackenzie McDonald
Benoît Paire →replaced by 
Jiří Veselý| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 Japan | Ben McLachlan |  United Kingdom | Joe Salisbury | 63 | 1 | |
 New Zealand | Marcus Daniell | Wesley Koolhof | 87 | 2 | ||
| Czech Republic | Roman Jebavý |  Argentina | Andrés Molteni | 97 | 3 | |
 Sweden | Robert Lindstedt | United States | Rajeev Ram | 98 | 4 |
The following pairs received wildcards into the doubles main draw:
See main article: 2018 ATP Shenzhen Open – Singles.
Yoshihito Nishioka def. Pierre-Hugues Herbert, 7–5, 2–6, 6–4See main article: 2018 ATP Shenzhen Open – Doubles.
Ben McLachlan / Joe Salisbury def. Robert Lindstedt / Rajeev Ram, 7–6(7–5), 7–6(7–4).
