The 2018 AON Open Challenger was a professional tennis tournament played on clay courts. It was the sixteenth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Genoa, Italy between 4 and 9 September 2018.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 France | ||||
 Slovakia | Martin Kližan | 71 | 2 | |
 Italy | Paolo Lorenzi | 94 | 3 | |
 Poland | Hubert Hurkacz | 109 | 4 | |
 Argentina | Federico Delbonis | 111 | 5 | |
| Argentina | Guido Andreozzi | 113 | 6 | |
 Brazil | Thiago Monteiro | 118 | 7 | |
| Italy | Lorenzo Sonego | 121 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
See main article: 2018 AON Open Challenger – Singles.
Lorenzo Sonego def. Dustin Brown 6–2, 6–1.See main article: 2018 AON Open Challenger – Doubles.
Martin Kližan / Filip Polášek 6–2, 3–6, [10–2].
