The women's 100m freestyle events at the 2017 World Para Swimming Championships were held in Mexico City between 2–7 December.[1]
| S3 | Peng Qiuping China | Zulfiya Gabidullina Kazakhstan | Alexandra Stamatopoulou Greece | |
| S4 | Monica Boggioni Italy | Patricia Pereira dos Santos Brazil | Sonja Sigurdardottir Iceland | |
| S5 | Sarah Louise Rung Norway | Teresa Perales Spain | Inbal Pezaro Israel | |
| S6 | Vianney Trejo Delgadillo Mexico | Ayaallah Tewfick Egypt | Sophia Elizabeth Herzog United States | |
| S7 | McKenzie Coan United States | Denise Grahl Germany | Ke Liting China | |
| S8 | Jessica Long United States | Cecilia Jeronimo de Araujo Brazil | Julia Gaffney United States | |
| S9 | Sarai Gascon Spain | Nuria Marqués Soto Spain | Natalie Sims United States | |
| S10 | Alessia Scortechini Italy | Chen Yi China | Bianka Pap Hungary | |
| S11 | Matilde Alcázar Mexico | McClain Hermes United States | Tatiana Blattnerová Slovakia | |
| S12 | Naomi Maike Schnittger Germany | Aspen Shelton United States | Maria Delgado Nadal Spain | |
| S13 | Carlotta Gilli Italy | Rebecca Meyers United States | Ariadna Edo Beltrán Spain |