The men's 50m freestyle events at the 2017 World Para Swimming Championships were held in Mexico City between 2–7 December.[1]
| S3 | Huang Wenpan China | Diego Lopez Diaz Mexico | Vincenzo Boni Italy | |
| S4 | Jan Povýšil Czech Republic | Gustavo Sanchez Martinez Mexico | Jesús Hernández Hernández Mexico | |
| S5 | Daniel Dias Brazil | Vo Thanh Tung | Sebastian Rodriguez Spain | |
| S6 | Nelson Crispín Colombia | Lorenzo Perez Escalona Cuba | Oscar Andres Osorio Campaz Colombia | |
| S7 | Carlos Serrano Zárate Colombia | Christian Sadie South Africa | Tobias Pollap Germany | |
| S8 | Xu Haijiao China | Yang Guanglong China | Luis Armando Andrade Guillen Mexico | |
| S9 | Simone Barlaam Italy | Jose Antonio Mari Alcaraz Spain | Leo Lähteenmäki Finland | |
| S10 | Phelipe Andrews Melo Rodrigues Brazil | Andre Brasil Brazil | David Levecq Spain | |
| S11 | Edgaras Matakas Lithuania | Hryhory Zudzilau Belarus | Wojciech Makowski Poland | |
| S12 | Tucker Dupree United States | Charalampos Taiganidis Greece | Thomaz Rocha Matera Brazil | |
| S13 | Ihar Boki Belarus | Kamil Rzetelski Poland | Ivan Salguero Oteiza Spain |