The 2017 Winston–Salem Open was a men's tennis tournament played on outdoor hard courts. It was the 49th edition of the Winston-Salem Open (as successor to previous tournaments in New Haven and Long Island), and part of the ATP World Tour 250 Series of the 2017 ATP World Tour. It took place at Wake Forest University in Winston-Salem, North Carolina, United States, from August 20 through August 26, 2017. It was the last event on the 2017 US Open Series before the 2017 US Open.
| Country | Player | Rank* | Seed | |
|---|---|---|---|---|
 Spain | Roberto Bautista Agut | 14 | 1 | |
| Spain | 17 | 2 | ||
| 19 | 3 | |||
| 28 | 5 | |||
| 36 | 6 | |||
 Italy | 37 | 7 | ||
| Spain | 40 | 8 | ||
 France | Gilles Simon | 42 | 9 | |
 Japan | 46 | 10 | ||
 Serbia | 47 | 11 | ||
 United Kingdom | 48 | 12 | ||
 Korea, Republic of | Chung Hyeon | 49 | 13 | |
| 50 | 14 | |||
 Russian Federation | 51 | 15 | ||
 Czech Republic | 52 | 16 | ||
| João Sousa | 54 | 17 |
The following players received wildcards into the singles main draw:
The following players received entry using a protected ranking:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Nikoloz Basilashvili →replaced by 
Thiago Monteiro Thomaz Bellucci →replaced by Jonathan Eysseric
Ryan Harrison →replaced by Thomas Fabbiano Nicolas Mahut →replaced by Andreas Seppi Sam Querrey →replaced by Andrey Rublev
Diego Schwartzman →replaced by 
Norbert Gombos| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 Colombia | Colombia | |||||
| Jean-Julien Rojer |  Romania | Horia Tecău | 49 | 2 | ||
| Mate Pavić | Serbia | Nenad Zimonjić | 57 | 3 | ||
| Brian Baker | Nikola Mektić | 66 | 4 |
The following pairs received wildcards into the doubles main draw:
The following pair received entry as alternates:
See main article: 2017 Winston-Salem Open – Singles.
Roberto Bautista Agut def. 
Damir Džumhur, 6–4, 6–4See main article: 2017 Winston-Salem Open – Doubles.
Horia Tecău def. Julio Peralta / Horacio Zeballos, 6–3, 6–4
