| Date: | 6–12 November |
| Edition: | 13th |
| Surface: | Clay |
| Location: | Montevideo, Uruguay |
| Champs: | Pablo Cuevas |
| Champd: | Romain Arneodo /  Fernando Romboli |
The 2017 Uruguay Open was a professional tennis tournament played on clay courts. It was the thirteenth edition of the tournament which was part of the 2017 ATP Challenger Tour. It took place in Montevideo, Uruguay between November 6 and 12, 2017.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Pablo Cuevas | 36 | 1 | ||
 Argentina | Guido Pella | 64 | 2 | |
| Argentina | Nicolás Kicker | 82 | 3 | |
| Brazil | Rogério Dutra Silva | 95 | 4 | |
 Spain | Roberto Carballés Baena | 101 | 5 | |
 Italy | Marco Cecchinato | 102 | 6 | |
| Nicolás Jarry | 116 | 7 | ||
| Argentina | Carlos Berlocq | 120 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
See main article: 2017 Uruguay Open – Singles.
See main article: 2017 Uruguay Open – Doubles.
Fernando Romboli def. Ariel Behar / Fabiano de Paula 2–6, 6–4, [10–8].
