| Champ: |  Simona Halep |
| Runner: |  Kristina Mladenovic |
| Score: | 7–5, 6–7(5–7), 6–2 |
See main article: 2017 Mutua Madrid Open.
Defending champion Simona Halep defeated Kristina Mladenovic in the final, 7–5, 6–7(5–7), 6–2 to win the women's singles tennis title at the 2017 Madrid Open.
As a result of Serena Williams' withdrawal due to pregnancy, Angelique Kerber regained the WTA no. 1 ranking at the end of the tournament.