The 2017 Milex Open was a professional tennis tournament played on green clay courts. It was the third edition of the tournament which was part of the 2017 ATP Challenger Tour. It took place in Santo Domingo, Dominican Republic between 14 and 19 August 2017.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Bosnia and Herzegovina | Damir Džumhur | 73 | 1 | |
 Spain | Nicolás Almagro | 81 | 2 | |
 Argentina | Guido Pella | 92 | 3 | |
 Dominican Republic | Víctor Estrella Burgos | 107 | 4 | |
 Norway | Casper Ruud | 111 | 5 | |
 Colombia | Santiago Giraldo | 118 | 6 | |
| Nicolás Jarry | 138 | 7 | ||
| Gastão Elias | 173 | 8 |
The following players received wildcards into the singles main draw:
Roberto Cid Subervi
Charles Force Nick Hardt José OlivaresThe following player received entry into the singles main draw as a special exempt:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Carlos Boluda-Purkiss Juan Ignacio Londero Cristian RodríguezThe following player received entry as a lucky loser:
See main article: 2017 Milex Open – Singles.
Víctor Estrella Burgos def. Damir Džumhur 7–6(7–4), 6–4.See main article: 2017 Milex Open – Doubles.
Juan Ignacio Londero / 
Luis David Martínez def. Daniel Elahi Galán / Santiago Giraldo 6–4, 6–4.