| Champ: |  Sam Querrey |
| Runner: |  Thanasi Kokkinakis |
| Score: | 6–3, 3–6, 6–2 |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| Edition: | 2nd |
| Type: | singles doubles |
See main article: 2017 Los Cabos Open.
Sam Querrey defeated Thanasi Kokkinakis in the final, 6–3, 3–6, 6–2 to win the singles tennis title at the 2017 Los Cabos Open. It was his ninth ATP Tour singles title.
Ivo Karlović was the defending champion, but lost in the first round to Quentin Halys.
The top four seeds receive a bye into the second round.
