| Champ: | Alexander Zverev |
| Runner: |  Novak Djokovic |
| Score: | 6–4, 6–3 |
| Draw: | 56 (7 / 4) |
| Seeds: | 16 |
See main article: 2017 Italian Open (tennis).
Alexander Zverev defeated Novak Djokovic in the final, 6–4, 6–3 to win the men's singles tennis title at the 2017 Italian Open. It was his first Masters 1000 title, and he became the first player born in the 1990s to win a Masters title.
Andy Murray was the defending champion, but lost in the second round to Fabio Fognini.
The top eight seeds receive a bye into the second round.