| Date: | 30 October – 4 November |
| Edition: | 13th |
| Surface: | Clay |
| Location: | Guayaquil, Ecuador |
| Champs: |  Gerald Melzer |
| Champd: | Marcelo Arévalo /  Miguel Ángel Reyes-Varela |
The 2017 Challenger Ciudad de Guayaquil was a professional tennis tournament played on clay courts. It was the thirteenth edition of the tournament which was part of the 2017 ATP Challenger Tour. It took place in Guayaquil, Ecuador between October 30 and November 4, 2017.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Dominican Republic | 80 | 1 | ||
 Argentina | 86 | 2 | ||
 Spain | Roberto Carballés Baena | 99 | 3 | |
 Italy | Marco Cecchinato | 108 | 4 | |
| Argentina | 117 | 5 | ||
| Gastão Elias | 128 | 6 | ||
| Austria | Gerald Melzer | 138 | 7 | |
 Norway | Casper Ruud | 139 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry as alternates:
The following players received entry from the qualifying draw:
See main article: 2017 Challenger Ciudad de Guayaquil – Singles.
Gerald Melzer def. Facundo Bagnis 6–3, 6–1.See main article: 2017 Challenger Ciudad de Guayaquil – Doubles.
Miguel Ángel Reyes-Varela def. 
Hugo Dellien / Federico Zeballos 6–1, 6–7(7–9), [10–6].
