| Champ: |  Gustavo Fernández |
| Runner: |  Nicolas Peifer |
| Score: | 3–6, 6–2, 6–0 |
| Before Name: | Australian Open – Wheelchair men's singles |
See main article: 2017 Australian Open.
Gustavo Fernández defeated Nicolas Peifer in the final, 3–6, 6–2, 6–0 to win the men's singles wheelchair tennis title at the 2017 Australian Open. It was his first Australian Open singles title and second major singles title overall.
Gordon Reid was the defending champion, but was defeated in the quarterfinals by Joachim Gérard.