| Date: | 7–13 March |
| Edition: | 1st |
| Draw: | 32S / 16D |
| Surface: | Hard |
| Prize Money: | $50,000+H |
| Location: | Zhuhai, China |
| Champs: |  Thomas Fabbiano |
| Champd: |  Gong Maoxin / Yi Chu-huan |
| After Name: | Zhuhai Open |
The 2016 Zhuhai Challenger was a professional tennis tournament played on hard courts. It was the first edition of the tournament which was part of the 2016 ATP Challenger Tour. It took place in Zhuhai, China between 7 and 13 March 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 India | Yuki Bhambri | 111 | 1 | |
 Georgia | Nikoloz Basilashvili | 118 | 2 | |
 Australia | Jordan Thompson | 123 | 3 | |
| Italy | Thomas Fabbiano | 126 | 4 | |
| India | Saketh Myneni | 156 | 5 | |
| Franko Škugor | 163 | 6 | ||
| China | Wu Di | 172 | 7 | |
 Russian Federation | Alexander Kudryavtsev | 179 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Cheong-Eui Kim
Maximilian Neuchrist Lorenzo SonegoSee main article: 2016 Zhuhai Challenger – Singles.
Thomas Fabbiano def. Zhang Ze, 5–7, 6–1, 6–3[1]See main article: 2016 Zhuhai Challenger – Doubles.
Gong Maoxin / Yi Chu-huan def. Hsieh Cheng-peng / Wu Di, 2–6, 6–1, [10–5]