| Competition: | Liga Profesional de Primera División |
| Season: | 2016 |
| Winners: | Nacional (46th title) |
| Relegated: | Villa Española |
| Continentalcup1: | 2017 Copa Libertadores |
| Continentalcup1 Qualifiers: | Nacional Montevideo Wanderers |
| Continentalcup2: | 2017 Copa Sudamericana |
| Continentalcup2 Qualifiers: | Danubio Defensor Sporting Liverpool Boston River |
| League Topscorer: | Gabriel Fernández Pablo Silva (8 goals each) |
| Prevseason: | 2015–16 |
| Nextseason: | 2017 |
The 2016 Liga Profesional de Primera División season, also known as the Campeonato Uruguayo Especial o Campeonato Transición, was the 113th season of Uruguay's top-flight football league, and the 86th in which it is professional. Peñarol was the defending champion.
Source: Soccerway
| width=28 | width=185 | Team | width=50 | width=50 | width=50 | width=50 | width=50 | width=50 | Relegation | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Nacional | 63 | 54 | 34 | 151 | 74 | ||||||||||
| 2 | Peñarol | 55 | 58 | 15 | 128 | 74 | ||||||||||
| 3 | Defensor Sporting | 48 | 42 | 25 | 115 | 75 | ||||||||||
| 4 | Danubio | 49 | 35 | 29 | 113 | 75 | ||||||||||
| 5 | River Plate | 54 | 41 | 18 | 113 | 75 | ||||||||||
| 6 | Montevideo Wanderers | 34 | 48 | 29 | 111 | 75 | ||||||||||
| 7 | Boston River | — | — | 22 | 22 | 15 | ||||||||||
| 8 | Cerro | 34 | 52 | 22 | 108 | 75 | ||||||||||
| 9 | Liverpool | — | 40 | 24 | 64 | 45 | ||||||||||
| 10 | Fénix | 37 | 46 | 19 | 102 | 75 | ||||||||||
| 11 | Sud América | 42 | 43 | 17 | 102 | 75 | ||||||||||
| 12 | Plaza Colonia | — | 49 | 12 | 61 | 45 | ||||||||||
| 13 | Racing | 45 | 31 | 20 | 96 | 75 | ||||||||||
| 14 | Juventud | 45 | 33 | 17 | 95 | 75 | ||||||||||
| 15 | — | — | 17 | 17 | 15 | |||||||||||
| 16 | Villa Española | — | — | 7 | 7 | 15 | Relegation to Segunda División |