| Competition: | Liga Profesional de Primera División |
| Season: | 2016 |
| Winners: | Nacional (46th title) |
| Relegated: | Villa Española |
| Continentalcup1: | 2017 Copa Libertadores |
| Continentalcup1 Qualifiers: | Nacional Montevideo Wanderers |
| Continentalcup2: | 2017 Copa Sudamericana |
| Continentalcup2 Qualifiers: | Danubio Defensor Sporting Liverpool Boston River |
| League Topscorer: | Gabriel Fernández Pablo Silva (8 goals each) |
| Prevseason: | 2015–16 |
| Nextseason: | 2017 |
The 2016 Liga Profesional de Primera División season, also known as the Campeonato Uruguayo Especial o Campeonato Transición, was the 113th season of Uruguay's top-flight football league, and the 86th in which it is professional. Peñarol was the defending champion.
| Club | City | Stadium | Capacity | |
|---|---|---|---|---|
| Boston River | Montevideo | Juan Antonio Lavalleja | 7,000 | |
| Cerro | Montevideo | Luis Tróccoli | 24,000 | |
| Danubio | Montevideo | Jardines Del Hipódromo | 14,401 | |
| Defensor Sporting | Montevideo | Luis Franzini | 18,000 | |
| Fénix | Montevideo | Parque Capurro | 5,500 | |
| Juventud | Las Piedras | Parque Artigas | 5,500 | |
| Liverpool | Montevideo | Belvedere | 10,000 | |
| Montevideo Wanderers | Montevideo | Parque Alfredo Víctor Viera | 7,420 | |
| Nacional | Montevideo | Gran Parque Central | 23,500 | |
| Peñarol | Montevideo | Campeón del Siglo | 40,000 | |
| Plaza Colonia | Colonia | Suppici | 12,000 | |
| Racing | Montevideo | Osvaldo Roberto | 4,500 | |
| Rampla Juniors | Montevideo | Olímpico | 9,500 | |
| River Plate | Montevideo | Parque Federico Omar Saroldi | 5,624 | |
| Sud América | San José | Casto Martínez Laguarda | 6,000 | |
| Villa Española | Montevideo | Obdulio Varela | 8,000 |
| Rank | Name | Club | Goals |
|---|---|---|---|
| 1 | Gabriel Fernández | Racing | 8 |
| Pablo Silva | Villa Española | 8 | |
| 3 | Líber Quiñones | Racing | 7 |
| Federico Rodríguez | Boston River | 7 | |
| 5 | Sebastián Fernández | Nacional | 6 |
| Maureen Franco | Cerro | 6 | |
| Martín Ligüera | Nacional | 6 |
Source: Soccerway
| width=28 | width=185 | Team | width=50 | width=50 | width=50 | width=50 | width=50 | width=50 | Relegation | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Nacional | 63 | 54 | 34 | 151 | 74 | ||||||||||
| 2 | Peñarol | 55 | 58 | 15 | 128 | 74 | ||||||||||
| 3 | Defensor Sporting | 48 | 42 | 25 | 115 | 75 | ||||||||||
| 4 | Danubio | 49 | 35 | 29 | 113 | 75 | ||||||||||
| 5 | River Plate | 54 | 41 | 18 | 113 | 75 | ||||||||||
| 6 | Montevideo Wanderers | 34 | 48 | 29 | 111 | 75 | ||||||||||
| 7 | Boston River | — | — | 22 | 22 | 15 | ||||||||||
| 8 | Cerro | 34 | 52 | 22 | 108 | 75 | ||||||||||
| 9 | Liverpool | — | 40 | 24 | 64 | 45 | ||||||||||
| 10 | Fénix | 37 | 46 | 19 | 102 | 75 | ||||||||||
| 11 | Sud América | 42 | 43 | 17 | 102 | 75 | ||||||||||
| 12 | Plaza Colonia | — | 49 | 12 | 61 | 45 | ||||||||||
| 13 | Racing | 45 | 31 | 20 | 96 | 75 | ||||||||||
| 14 | Juventud | 45 | 33 | 17 | 95 | 75 | ||||||||||
| 15 | — | — | 17 | 17 | 15 | |||||||||||
| 16 | Villa Española | — | — | 7 | 7 | 15 | Relegation to Segunda División |