| Champ: |  Diego Schwartzman |
| Runner: |  Rogério Dutra Silva |
| Score: | 6–4, 6–1 |
| Type: | singles doubles |
See main article: article and 2016 Uruguay Open.
Guido Pella was the defending champion but chose not to defend his title.
Diego Schwartzman won the title after defeating Rogério Dutra Silva 6–4, 6–1 in the final.