The 2016 Torneo de Mendoza was a professional tennis tournament played on clay courts. It was the first edition of the tournament, which was part of the 2016 ATP Challenger Tour. It took place in Mendoza, Argentina from 5 to 10 January 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Horacio Zeballos | 124 | 1 | ||
 Brazil | Rogério Dutra Silva | 125 | 2 | |
 Spain | Roberto Carballés Baena | 131 | 3 | |
 Argentina | Facundo Argüello | 137 | 4 | |
| Argentina | Facundo Bagnis | 140 | 5 | |
 Slovakia | Andrej Martin | 146 | 6 | |
| Argentina | Máximo González | 147 | 7 | |
 Austria | Gerald Melzer | 166 | 8 |
The following players received wildcards into the singles main draw:
Francisco Bahamonde
The following players received entry from the qualifying draw:
Maximiliano Estévez Juan Ignacio Galarza Thiago MonteiroSee main article: article and 2016 Torneo de Mendoza – Singles.
Gerald Melzer def. 
Axel Michon 4–6, 6–4, 6–0[1]See main article: article and 2016 Torneo de Mendoza – Doubles.
Máximo González / 
José Hernández def. Julio Peralta / Horacio Zeballos 4–6, 6–3, [10–1]