| Year: | 2016 |
| Team: | Southeast Missouri State Redhawks |
| Sport: | football |
| Conference: | Ohio Valley Conference |
| Short Conf: | OVC |
| Record: | 3–8 |
| Conf Record: | 3–5 |
| Head Coach: | Tom Matukewicz |
| Hc Year: | 3rd |
| Off Coach: | Jon Wiemers |
| Oc Year: | 1st |
| Def Coach: | Bryce Saia |
| Dc Year: | 3rd |
| Stadium: | Houck Stadium |
The 2016 Southeast Missouri State Redhawks football team represented Southeast Missouri State University as a member of the Ohio Valley Conference (OVC) during the 2016 NCAA Division I FCS football season. Led by third-year head coach Tom Matukewicz, the Redhawks compiled an overall record of 3–8 with a mark of 3–5 in conference play, placing seventh in the OVC. Southeast Missouri State played home games at Houck Stadium in Cape Girardeau, Missouri.
See also: 2016 Memphis Tigers football team.
See also: 2016 Southern Illinois Salukis football team.
See also: 2016 Indiana State Sycamores football team.
See also: 2016 Murray State Racers football team.
See also: 2016 Eastern Illinois Panthers football team.
See also: 2016 Eastern Kentucky Colonels football team.
See also: 2016 Tennessee Tech Golden Eagles football team.
See also: 2016 Austin Peay Governors football team.
See also: 2016 Jacksonville State Gamecocks football team.
See also: 2016 UT Martin Skyhawks football team.
See also: 2016 Tennessee State Tigers football team.