| Date: | 17–23 October |
| Edition: | 2nd |
| Category: | ITF Women's Circuit |
| Location: | Sharm el-Sheikh, Egypt |
| Surface: | Hard |
| Prize Money: | $100,000 |
| Champs: | Donna Vekić |
| Champd: |  Irina Maria Bara /  Alona Fomina |
| Before Year: | 2013 |
The 2016 Soho Square Ladies Tournament was a professional tennis tournament played on outdoor hard courts. It was the 2nd edition of the tournament and part of the 2016 ITF Women's Circuit, offering a total of $100,000 in prize money. It took place in Sharm el-Sheikh, Egypt, on 17–23 October 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Japan | Nao Hibino | 84 | 1 | |
| Maria Sakkari | 97 | 2 | ||
| Romania | Ana Bogdan | 118 | 3 | |
| Donna Vekić | 120 | 4 | ||
 Spain | Sara Sorribes Tormo | 127 | 5 | |
| Spain | Sílvia Soler Espinosa | 129 | 6 | |
| Cindy Burger | 138 | 7 | ||
| Amra Sadiković | 146 | 8 |
The following player received a wildcard into the singles main draw:
Ola Abou Zekry Lamis Alhussein Abdel Aziz
Vitalia Diatchenko Ana Bianca MihăilăThe following players received entry from the qualifying draw:
The following player received entry by a lucky loser spot:
See main article: 2016 Soho Square Ladies Tournament – Singles.
Sara Sorribes Tormo, 6–2, 6–7(7–9), 6–3See main article: 2016 Soho Square Ladies Tournament – Doubles.
Irina Maria Bara / Alona Fomina def. 
Guadalupe Pérez Rojas / Jil Teichmann, 6–2, 6–1