| Champ: |  Máximo González |
| Runner: |  Rogério Dutra Silva |
| Score: | 6–2, 7–6(7–5) |
| Type: | singles doubles |
See main article: 2016 Santiago Challenger.
Rogério Dutra Silva was the defending champion but lost in the final to Máximo González.
González won the title after defeating Dutra Silva 6–2, 7–6(7–5) in the final.