| Champ: |  Peđa Krstin |
| Runner: | Marcelo Arévalo |
| Score: | 6–4, 6–2 |
| Type: | singles doubles |
See main article: 2016 San Luis Open Challenger Tour.
Guido Pella was the defending champion, but chose not to defend his title.
Peđa Krstin won the title, defeating Marcelo Arévalo 6–4, 6–2 in the final.