| League Topscorer: | Aliou Seck (12 Goals) |
| Biggest Home Win: | Assumption United 7–0 Thonburi City (4 September 2016) |
| Biggest Away Win: | Thonburi City 0–5 Krung Thonburi (20 March 2016) |
| Highest Scoring: | Chumphon 5–3 Assumption United (29 May 2016) |
| Matches: | 132 |
| Total Goals: | 328 |
| Nextseason: | (T4) 2017 |
2016 Regional League Division 2 Western Region is the 4th season of the League competition since its establishment in 2013. It is in the third tier of the Thai football league system.
Nonthaburi, Krung Thonburi, Globlex, Ratchaphruek College, Thonburi City, Samut Sakhon, Hua Hin City and Simork are broken from Central & Western Region
No club was promoted to the Thai Division 1 League. Last years league champions Samut Sakhon and runners up Thonburi City failed to qualify from the 2015 Regional League Division 2 championsleague round.
Muangkan United is returning to the league after a 1-year break.
IPE Samut Sakhon Promoted from Khǒr Royal Cup (ถ้วย ข.) 2015 Champion
| Team | Location | Stadium | Capacity | |
|---|---|---|---|---|
| Assumption United | Nonthaburi | Assumption Thonburi School Stadium(Wongprachanukul Stadium) | 1,000 | [1] |
| BTU United | Bangkok | Bangkok-Thonburi University Stadium | 5,000 | [2] |
| Chumphon | Chumphon | IPE Chumphon Stadium | 3,000 | [3] |
| IPE Samut Sakhon United | Samut Sakhon | IPE Samut Sakhon Stadium | 6,000 | [4] |
| Hua Hin City | Prachuap Khiri Khan | 3,500 | [5] | |
| Krung Thonburi | Nakhon Pathom | Mahidol University Salaya Campus Stadium | 2,000 | [6] |
| Muangkan United | Kanchanaburi | Kleab Bua Stadium | 13,000 | [7] |
| Nonthaburi | Nonthaburi | Nonthaburi Sports Complex Stadium | 10,000 | [8] |
| Ratchaphruek University | Bangkok | Thonburi University Stadium | ? | [9] |
| Samut Sakhon | Samut Sakhon | ? | [10] | |
| Simork | Suphanburi | Suphanburi Sports School Stadium | 1,500 | [11] |
| Bangkok | Bang Bon Sport Center | 5,000 | [12] | |
As of 4 September 2016.
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 |  Aliou Seck | 12 | |
| 2 | Kingsley Obioma | Krung Thonburi | 11 |
| 3 |  Jatuchai Thongbut | Krung Thonburi | 10 |
| Sirimongkhon Jitbanjong | Simork | ||
| 5 |  Song Il-eum | BTU United | 8 |
 Yoshinari Sato | Chumphon | ||
 John Sam | Nonthaburi | ||
| Yodsak Chaowana | Assumption United | ||
| Samuel Ampofo | Ratchaphruek University | ||
| 10 | Issac Nikwei | Ratchaphruek University | 7 |
 Moussa Abakar | Simork | ||