| Date: | 26 September–2 October |
| Edition: | 8th |
| Category: | ITF Women's Circuit |
| Location: | Las Vegas, United States |
| Prize Money: | $50,000 |
| Champs: |  Alison Van Uytvanck |
| Champd: | Michaëlla Krajicek /  Maria Sanchez |
The 2016 Red Rock Pro Open was a professional tennis tournament played on outdoor hard courts. It was the 8th edition of the tournament and part of the 2016 ITF Women's Circuit, offering a total of $50,000 in prize money. It took place in Las Vegas, United States, on 26 September–2 October 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Belgium | Alison Van Uytvanck | 103 | 1 | |
 Luxembourg | Mandy Minella | 112 | 2 | |
| United States | Julia Boserup | 116 | 3 | |
| Belgium | Elise Mertens | 122 | 4 | |
| Verónica Cepede Royg | 127 | 5 | ||
| United States | Taylor Townsend | 142 | 6 | |
| Montserrat González | 151 | 7 | ||
| United States | Sachia Vickery | 154 | 8 |
The following player received a wildcard into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry by a lucky loser spot:
See main article: 2016 Red Rock Pro Open – Singles.
Alison Van Uytvanck def. Sofia Kenin, 3–6, 7–6(7–4), 6–2See main article: 2016 Red Rock Pro Open – Doubles.
Maria Sanchez def. Jamie Loeb / Chanel Simmonds, 7–5, 6–1
