| Date: | 12–18 September |
| Edition: | 24th |
| Surface: | Clay |
| Location: | Szczecin, Poland |
| Champs: |  Alessandro Giannessi |
| Champd: | Andre Begemann /  Aliaksandr Bury |
The 2016 Pekao Szczecin Open was a professional tennis tournament played on clay courts. It was the 24th edition of the tournament which was part of the 2016 ATP Challenger Tour. It took place in Szczecin, Poland between 12 and 18 September 2016.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Marcel Granollers | 45 | 1 | |
| Spain | Íñigo Cervantes | 75 | 2 | |
| Dustin Brown | 86 | 3 | ||
 Moldova, Republic of | Radu Albot | 97 | 4 | |
 Georgia | Nikoloz Basilashvili | 102 | 5 | |
 Russian Federation | Teymuraz Gabashvili | 105 | 6 | |
| Spain | Albert Montañés | 135 | 7 | |
| Italy | Marco Cecchinato | 140 | 8 |
The following players received wildcards into the singles main draw:
Marcel Granollers
Casper Ruud
Paweł Ciaś Michał PrzysiężnyThe following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Vladimir Ivanov
Petr MichnevSee main article: 2016 Pekao Szczecin Open – Singles.
Alessandro Giannessi def. Dustin Brown, 6–2, 6–3.See main article: 2016 Pekao Szczecin Open – Doubles.
Aliaksandr Bury def. 
Johan Brunström / Andreas Siljeström, 7–6(7–2), 6–7(7–9), [10–4].