| Champ: |  Dominic Thiem |
| Score: | 6–4, 3–6, 6–0 |
| Draw: | 28 |
| Seeds: | 8 |
| Type: | singles doubles |
| After Year: | no |
See main article: article and 2016 Open de Nice Côte d'Azur. Dominic Thiem was the defending champion and successfully defended his title, defeating Alexander Zverev in the final, 6–4, 3–6, 6–0.
The top four seeds receive a bye into the second round.